P0300 on GMC vehicles Misfire detected, but not isolated to one cylinder

A model year is listed because the code is named in its own record — a bulletin filed against it, or an owner’s complaint about it — not because every one of these vehicles sets it. Counts are documents in NHTSA’s files, not failure rates.

Bulletins and campaigns GMC filed with NHTSA whose summary names P0300. Quote the document number at the service desk — it is a diagnosis the maker has already written down.

• SB-15-06-01-002C Service bulletin
  2016-05-01 · Engine
• THIS TECHNICAL BULLETIN PROVIDES A PROCEDURE TO REPLACE THE VALVE LIFTER OIL MANIFOLD AND AFFECTED BANK OF AFM LIFTERS TO CORRECT A CUSTOMER CONCERN ON A MALFUNCTION INDICATOR LAMP (MIL) ON AND/OR AN ENGINE MISFIRE/TICK NOISE WITH DTC P0300 SET DUE TO AN ACTIVE FUEL MANAGEMENT (AFM) LIFTER THAT IS MECHANICALLY COLLAPSED AND/OR STUCK ALL OF THE TIME.
• PIP5498E Service bulletin
  2017-12-11 · Engine And Engine Cooling
• This Preliminary information communicates A vehicle may have a concern of DTCP050D setting along with a P0300 after a cold start up. White smoke and/or coolant odor may come from exhaust for an extended period of time at cold start as well. Cause Coolant getting into the cylinders, and provides direction for the repair.
• PIP5323 Service bulletin
  2015-09-01 · Engine And Engine Cooling
• This Preliminary Information communication provides information to the technician about vehicles with misfires or roughness on cold start up. Technician may find a Diagnostic Trouble Code P0300 stored. Technician will add coolant dye to the system, run engine through warm up, pressurize the cooling system on a cold soak engine and inspect the suspect cylinder with a bore scope for coolant dye evid
• PIP5498H Service bulletin
  2018-05-18 · Equipment
• This Preliminary information communicates A vehicle may have a concern of DTCP050D setting along with a P0300 after a cold start up. White smoke and/or coolant odor may come from exhaust for an extended period of time at cold start as well. Cause: Coolant getting into the cylinders, and provides direction for the repair.
• PIP5498J Service bulletin
  2018-06-06 · Engine And Engine Cooling
• This Preliminary information communicates. A vehicle may have a concern of DTCP050D setting along with a P0300 after a cold start up. White smoke and/or coolant odor may come from exhaust for an extended period of time at cold start as well. Cause Coolant getting into the cylinders, and provides direction for the repair.
• PIP5511A Service bulletin
  2018-01-23 · Engine And Engine Cooling — Cooling System
• This Preliminary information communicates the potential for a flashing MIL and DTC p0300 to occur in areas of high amounts of rain fall or humidity. This is due to the moisture that can accumulate in the charge air cooler from the rapid cooling of the internal air and be ingested into the engine.
• PIP5511 Service bulletin
  2017-08-04 · Engine
• This Preliminary information communicates the potential for a flashing MIL and DTC p0300 to occur in areas of high amounts of rain fall or humidity. This is due to the moisture that can accumulate in the charge air cooler from the rapid cooling of the internal air and be ingested into the engine.
• PIP5628 Service bulletin
  2019-02-18 · Engine And Engine Cooling
• This Preliminary information communicates information that will need to be provided to TAC to aid in diagnosing if a vehicle comes in with misfire and DTC Codes P0300 - P0308 and/or P050D
• 18NA020 Service bulletin
  2019-02-19 · Engine And Engine Cooling
• This technical bulletin provides a procedure to replace the charge air cooler due to moisture getting inside of it and causing a malfunction indicator lamp illuminated with DTC P0300 and/or P0299/P2227.
• PIE0505 Service bulletin
  2019-02-08 · Equipment — Other — Owners/Service/Other Manual
• This engineering informational bulletin is requesting information from the field to determine a root cause for a condition of Engine Running Rough and/or Check EngineLight Illuminated, DTCs P0300, P0301, P0302, P0303, P0304 Set.
• 18NA020 Service bulletin
  2019-03-19 · Engine And Engine Cooling
• This technical bulletin provides a procedure to replace the charge air cooler due to moisture getting inside of it and causing a malfunction indicator lamp illuminated with DTC P0300 and/or P0299/P2227.
• 21NA255 Service bulletin
  2021-11-09 · Electrical System — Ignition — Coil — Spark Plugs
• This service bulletin provides repair information to correct a customer concern of an Engine Misfire, Malfunction Indicator Lamp (MIL) Illuminated - DTC P0300 Set.

A stored code names the test that failed, never the part that caused it. The record above is what GMC and its owners have filed about it; the code’s page across every make has the whole file.