P0300 on Cadillac vehicles Misfire detected, but not isolated to one cylinder

A model year is listed because the code is named in its own record — a bulletin filed against it, or an owner’s complaint about it — not because every one of these vehicles sets it. Counts are documents in NHTSA’s files, not failure rates.

Owners’ own words, scrubbed of anything identifying. Unverified reports filed with NHTSA — what was said, not a finding that it was true.

Bulletins and campaigns Cadillac filed with NHTSA whose summary names P0300. Quote the document number at the service desk — it is a diagnosis the maker has already written down.

• SB-15-06-01-002C Service bulletin
  2016-05-01 · Engine
• THIS TECHNICAL BULLETIN PROVIDES A PROCEDURE TO REPLACE THE VALVE LIFTER OIL MANIFOLD AND AFFECTED BANK OF AFM LIFTERS TO CORRECT A CUSTOMER CONCERN ON A MALFUNCTION INDICATOR LAMP (MIL) ON AND/OR AN ENGINE MISFIRE/TICK NOISE WITH DTC P0300 SET DUE TO AN ACTIVE FUEL MANAGEMENT (AFM) LIFTER THAT IS MECHANICALLY COLLAPSED AND/OR STUCK ALL OF THE TIME.
• PIP5159B Service bulletin
  2016-09-23 · Engine
• THIS PRELIMINARY INFORMATION COMMUNICATION PROVIDES INFORMATION TO THE TECHNICIAN ABOUT VEHICLES THAT MAY HAVE A SERVICE ENGINE SOON MALFUNCTION INDICATOR LAMP ON AND DIAGNOSTIC TROUBLE CODE P0300 - P0308 MAY SET. TECHNICIAN WILL INSPECT FOR LOSE SPARKPLUG WIRE. IF A SPARK PLUG WIRE IS FOUND LOSE CHECK FOR A MISSING “C” CLIP ON THE WIRE END FOR THE IGNITION COIL. IF THE CLIP IS MISSING REPLACE TH
• GCUS-3-314 Service bulletin
  2015-10-13 · Engine And Engine Cooling
• 15638 - Customer Satisfaction Program. Certain 2016 model year Cadillac Escalade, Escalade ESV, Chevrolet Corvette, GMC Yukon Denali and 2015 Cadillac Escalade ESV, Chevrolet Silverado LD, GMC Sierra LD, and Yukon Denali XL model vehicles equipped with 6.2L engines (RPO L86 and LT1) may have engines built with cylinder head gaskets in which the head gasket stopper ring was off location. The gaske
• PIP5386 Service bulletin
  2016-03-22 · Equipment — Other — Owners/Service/Other Manual
• This Preliminary Information communication provides information to the technician with the steps to diagnose and repair vehicles that have Malfunction Indicator Lamp on with Diagnostic Trouble Codes P0264 or P0265 and P0300. This may be due to a wiring concern at the #2 fuel injector. Technician will gain access to the fuel injector be removing the intake manifold. Inspect the fuel injector wiring
• PIP5498E Service bulletin
  2017-12-11 · Engine And Engine Cooling
• This Preliminary information communicates A vehicle may have a concern of DTCP050D setting along with a P0300 after a cold start up. White smoke and/or coolant odor may come from exhaust for an extended period of time at cold start as well. Cause Coolant getting into the cylinders, and provides direction for the repair.
• PIP5553 Service bulletin
  2018-02-02 · Electrical System — Starter Assembly
• This Preliminary information communicatesThe vehicle may have an ses lamp with any of the following DTC P06DA, P06DB, P06DC, P06B6, P06B7, P250A, P0300, P0340, P0341, P0335, P0336, P0641, P0011, P0010, P2088, P2089, and/or P2230. Possible crank no start or a stall. possible wiring jumper harness chaffed at the bolt at the X154 connector on lower left side of the frount cover.
• PIP5498H Service bulletin
  2018-05-18 · Equipment
• This Preliminary information communicates A vehicle may have a concern of DTCP050D setting along with a P0300 after a cold start up. White smoke and/or coolant odor may come from exhaust for an extended period of time at cold start as well. Cause: Coolant getting into the cylinders, and provides direction for the repair.
• 18NA115 Service bulletin
  2018-04-13 · Engine And Engine Cooling
• This Bulletin provides inspection/diagnosis/correction information on a cold start misfire and/or rough idle and DTC P0300 that may also be set.
• PIP5752B Service bulletin
  2020-10-13 · Engine And Engine Cooling
• This Preliminary information communicates A Vehicle may have a concern of service engine light, misfire and  engine noise with possible of DTC P0300 P0106 P0506,  Possible valve spring concern
• PIP5752C Service bulletin
  2020-10-16 · Engine And Engine Cooling
• This Preliminary information communicates A Vehicle may have a concern of service engine light, misfire and  engine noise with possible of DTC P0300 P0106 P0506,  Possible valve spring concern
• PIP5752D Service bulletin
  2020-10-22 · Engine And Engine Cooling
• This Preliminary information communicates A Vehicle may have a concern of service engine light, misfire and  engine noise with possible of DTC P0300 P0106 P0506,  Possible valve spring concern
• PIP4959G Service bulletin
  2017-12-11 · Engine And Engine Cooling
• This Preliminary Information communication provides information to the technician with information regarding high misfire rates always on #1 cylinder. A customer may complain of misfires or roughness on cold start up with a P0300 diagnostic trouble code. Technician is to add coolant dye to the system and run the engine through warm up to circulate the dye. Pressurize the cooling system after a col

A stored code names the test that failed, never the part that caused it. The record above is what Cadillac and its owners have filed about it; the code’s page across every make has the whole file.