P0300 on Acura vehicles Misfire detected, but not isolated to one cylinder

A model year is listed because the code is named in its own record — a bulletin filed against it, or an owner’s complaint about it — not because every one of these vehicles sets it. Counts are documents in NHTSA’s files, not failure rates.

Bulletins and campaigns Acura filed with NHTSA whose summary names P0300. Quote the document number at the service desk — it is a diagnosis the maker has already written down.

• BEBM08262026901 Other
  2026-08-26 · Engine
• Dealer Message - Under certain conditions, the cylinder head gasket effectiveness may be reduced which may cause vehicles to experience overheating, coolant loss, misfire, and/or DTCs P0300 through P0304 stored.
• B26-002 Service bulletin
  2026-08-26 · Engine
• Service Bulletin - Under certain conditions, the cylinder head gasket effectiveness may be reduced which may cause vehicles to experience overheating, coolant loss, misfire and/or DTCs P0300 thru P0304 stored.
• B26-003 Service bulletin
  2026-08-26 · Engine
• Service Bulletin - Under certain conditions, the cylinder head gasket effectiveness may be reduced which may cause vehicles to experience overheating, coolant loss, misfire and/or DTCs P0300 thru P0304 stored.
• BPAS03222017902 Service bulletin
  2017-03-22 · Engine
• "DEALER MESSAGE - AMERICAN HONDA (AHM) IS INVESTIGATING CERTAIN 2016 MDX WITH A CLIENT COMPLAINT OF THE MALFUNCTION INDICATOR LAMP (MIL) ON WITH THE DTC P0300 (RANDOM MISFIRE DETECTED), P0301 (NO. 1 CYLINDER MISFIRE DETECTED), P0302 (NO. 2 CYLINDER MISFIRE DETECTED), P0303 (NO. 3 CYLINDER MISFIRE DETECTED), P0304 (NO. 4 CYLINDER MISFIRE DETECTED), P0305 (NO. 5 CYLINDER MISFIRE DETECTED) AND/OR P03
• BPAS04122017904 Service bulletin
  2017-04-12 · Equipment — Mechanical
• "DEALER MESSAGE - AMERICAN HONDA (AHM) IS INVESTIGATING CERTAIN 2016 MDX WITH A CLIENT COMPLAINT OF THE MALFUNCTION INDICATOR LAMP (MIL) ON WITH THE DTC P0300 (RANDOM MISFIRE DETECTED), P0301 (NO. 1 CYLINDER MISFIRE DETECTED), P0302 (NO. 2 CYLINDER MISFIRE DETECTED), P0303 (NO. 3 CYLINDER MISFIRE DETECTED), P0304 (NO. 4 CYLINDER MISFIRE DETECTED), P0305 (NO. 5 CYLINDER MISFIRE DETECTED) AND/OR P03
• BPAS04242017901 Service bulletin
  2017-04-24 · Engine
• "DEALER MESSAGE - AMERICAN HONDA (AHM) IS INVESTIGATING CERTAIN 2016 MDX WITH A CLIENT COMPLAINT OF THE MALFUNCTION INDICATOR LAMP (MIL) ON WITH THE DTC P0300 (RANDOM MISFIRE DETECTED), P0301 (NO. 1 CYLINDER MISFIRE DETECTED), P0302 (NO. 2 CYLINDER MISFIRE DETECTED), P0303 (NO. 3 CYLINDER MISFIRE DETECTED), P0304 (NO. 4 CYLINDER MISFIRE DETECTED), P0305 (NO. 5 CYLINDER MISFIRE DETECTED) AND/OR P03
• B26-001 Service bulletin
  2026-08-26 · Engine
• Service Bulletin - Under certain conditions, the cylinder head gasket effectiveness may be reduced which may cause vehicles to experience overheating, coolant loss, misfire and/or DTCs P0300 thru P0304 stored.
• B26-001 Service bulletin
  2026-09-25 · Engine
• Service Bulletin - Under certain conditions, the cylinder head gasket effectiveness may be reduced which may cause vehicles to experience overheating, coolant loss, and/or misfire. In some cases, DTCs P0300 through P0304 may also be stored (DTCs are not required for repair).
• B23-010 Service bulletin
  2023-03-14 · Engine And Engine Cooling
• Service Bulletin - Under certain circumstances, the vehicle may experience driveability concerns. This may result in the following DTC’s to set: • P0300 (Random Misfire Detected), • P0301 (No. 1 Cylinder Misfire Detected), • P0302 (No. 2 Cylinder Misfire Detected), • P0303 (No. 3 Cylinder Misfire Detected), • P0304 (No. 4 Cylinder Misfire Detected), • P0172 (Fuel System Too Ric

A stored code names the test that failed, never the part that caused it. The record above is what Acura and its owners have filed about it; the code’s page across every make has the whole file.